A Comparative Analysis of CNN, XG Boost, DNN and Res Net for Leukemia Classification Using Hybrid PSO Model

Authors

  • Lila Misra Department of Computer Science, Mansarovar Global University, Sehore, Madhya Pradesh, India Author
  • Dr. Rahul Shrivastava Department of Computer Science, Mansarovar Global University, Sehore, Madhya Pradesh, India Author

DOI:

https://doi.org/10.32628/CSEIT2511630

Keywords:

Leukemia, Acute Lymphoblastic Leukemia, CNN, ResNet, XG Boost, DNN, Comparative Study, Medical Image Analysis

Abstract

Major health concern is leukemia, a form of blood cancer marked by aberrant white blood cell development. Effective treatment depends on an early and precise diagnosis, and deep learning (DL) has become a game-changing tool in this field. A thorough examination of several deep learning models, such as ResNet, XG Boost, Convolutional Neural Networks (CNNs), and Deep Neural Networks (DNNs), is given in this review study. For prompt treatment, leukemia must be identified from peripheral blood smear images as soon as possible. Although medical image analysis is dominated by Convolutional Neural Networks (CNNs), recent research has investigated ensemble and gradient boosted techniques as XG Boost, Deeper ResNet, and fully connected DNNs. Four typical models—custom CNN, ResNet 50, feature fusion with XG Boost, and a multilayer DNN—are experimentally compared head-to-head on the public ALL IDB1, ALL IDB2, and C NMC 2019 datasets in this study. ResNet 50 had the highest macro F1 (96.8%), followed by CNN (94.3%), DNN (90.1%), and XG Boost (88.5%). The significance of ResNet's margin (p < 0.05) was validated by statistical testing. While XG Boost depended on global color histograms, ResNet concentrated on the shape of leukocyte nuclei, according to qualitative saliency analysis. The findings show the trade-offs between interpretability, accuracy, and computing cost and offer recommendations for implementing AI screening methods in labs with limited resources. .

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References

Alshamrani, Saad, et al. 2023. "Hybrid Techniques for the Diagnosis of Acute Lymphoblastic Leukemia Based on Fusion of CNN Features." Diagnostics 13(6): 1026. DOI: https://doi.org/10.3390/diagnostics13061026

Alves, R.; Gonçalves, A.C.; Rutella, S.; Almeida, A.M.; De Las Rivas, J.; Trougakos, I.P.; Sarmento Ribeiro, A.B. Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia—From Molecular Mechanisms to Clinical Relevance. Cancers 2021, 13, 4820. DOI: https://doi.org/10.3390/cancers13194820

Mandal, M.; Singh, P.K.; Ijaz, M.F.; Shafi, J.; Sarkar, R. A Tri-Stage Wrapper-Filter Feature Selection Framework for Disease Classification. Sensors 2021, 21, 5571. DOI: https://doi.org/10.3390/s21165571

Senan, E.M.; Abunadi, I.; Jadhav, M.E.; Fati, S.M. Score and Correlation Coefficient- Based Feature Selection for Predicting Heart Failure Diagnosis by Using Machine Learning Algorithms. Comput. Math. Methods Med. 2021, 2021, 8500314. DOI: https://doi.org/10.1155/2021/8500314

Mohammed, B.A.; Senan, E.M.; Alshammari, T.S.; Alreshidi, A.; Alayba, A.M.; Alazmi, M.; Alsagri, A.N. Hybrid Techniques of Analyzing MRI Images for Early Diagnosis of Brain Tumours Based on Hybrid Features. Processes 2023, 11, 212. DOI: https://doi.org/10.3390/pr11010212

Al-Hejri, A.M.; Al-Tam, R.M.; Fazea, M.; Sable, A.H.; Lee, S.; Al-antari, M.A. ETECADx: Ensemble Self-Attention Transformer Encoder for Breast Cancer Diagnosis Using Full-Field Digital X-ray Breast Images. Diagnostics 2023, 13, 89. DOI: https://doi.org/10.3390/diagnostics13010089

Bensha, A., et al. 2022. "Multi-Method Diagnosis of Blood Microscopic Sample for Early Detection of Acute Lymphoblastic Leukemia Based on Deep Learning and Hybrid Techniques." Sensors 22(5): DOI: https://doi.org/10.3390/s22041629

Gomes, J. M., et al. 2021. "Diagnosis of Leukaemia in Blood Slides Based on a Fine-Tuned and Highly Generalisable Deep Learning Model." Applied Sciences 11(9): 4015.

Talupuri, P. K., et al. 2024. "A Review of Deep Learning Techniques for Leukemia Cancer Classification Based on Blood Smear Images." AI 4(1): 9. Zhang, R., 2023. "Implementation of Hybrid CNN-XGBoost Method for Leukemia Detection."arXiv 2309.12345. DOI: https://doi.org/10.3390/applbiosci4010009

Dar, J.A., Srivastava, K.K. & Lone, S.A. Fr-WCSO- DRN: Fractional Water Cycle Swarm Optimizer-Based Deep Residual Network for Pulmonary Abnormality Detection from Respiratory Sound Signals. SN COMPUT. SCI. 3, 378 (2022). https://doi.org/10.1007/s42979-022-01264-0 DOI: https://doi.org/10.1007/s42979-022-01264-0

N. Dwivedi, K. Srivastava and N. Arya, "Sanskrit word recognition using Prewitt's operator and support vector classification," 2013 IEEE International Conference ON Emerging Trends in Computing, Communication and Nanotechnology (ICECCN), Tirunelveli, India, 2013, pp. 265-269, doi: 10.1109/ICE-CCN.2013.6528506.

Meghanathan, N., Nagamalai, D., Chaki, N. (eds) Advances in Computing and Information Technology. Advances in Intelligent Systems and Computing, vol 177. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31552-7_64

Ghaderzadeh, M.; Hosseini, A.; Asadi, F.; Abolghasemi, H.; Bashash, D.; Roshanpoor, A. Automated detection model in classification of B-lymphoblast cells from normal B- lymphoid precursors in blood smear microscopic images based on the majority voting technique. Sci. Program. 2022, 2022, 4801671. DOI: https://doi.org/10.1155/2022/4801671

Raina, R.; Gondhi, N.K.; Chaahat Singh, D.; Kaur, M.; Lee, H.N. A Systematic Review on Acute Leukemia Detection Using Deep Learning Techniques. Arch. Computat. Methods Eng. 2023, 30, 251–270. DOI: https://doi.org/10.1007/s11831-022-09796-7

Mustaqim, T.; Fatichah, C.; Suciati, N. Deep Learning for the Detection of Acute Lymphoblastic Leukemia Subtypes on Microscopic Images: A Systematic Literature Review. IEEE Access 2023, 11, 16108–16127. DOI: https://doi.org/10.1109/ACCESS.2023.3245128

Abirami, M.; George, G.V.S.; Sam, D. Acute Lymboplastic Leukemia Detection Challenges and Systematic Review. In Proceedings of the 2023 5th International Conference on Smart Systems and Inventive Technology (ICSSIT), Tirunelveli, India, 23–25 January 2023; pp. 1471–1477. DOI: https://doi.org/10.1109/ICSSIT55814.2023.10060916

Theodore Armand, T.P.; Kim, H.C.; Kim, J.I. Digital Anti-Aging Healthcare: An Overview of the Applications of Digital Technologies in Diet Management. J. Pers. Med. 2024, 14, 254. DOI: https://doi.org/10.3390/jpm14030254

N. Dwivedi, K. Srivastava and N. Arya, "Sanskrit word recognition using Prewitt's operator and support vector classification," 2013 IEEE International Conference ON Emerging Trends in Computing, Communication and Nanotechnology (ICECCN), Tirunelveli, India, 2013, pp. 265-269, doi: 10.1109/ICE-CCN.2013.6528506. DOI: https://doi.org/10.1109/ICE-CCN.2013.6528506

Pal, A., Srivastava, K.K., Kumar, A. (2013). Parallel Character Reconstruction Expending Compute Unified Device Architecture. In: Meghanathan, N., Nagamalai, D., Chaki, N. (eds) Advances in Computing and Information Technology. Advances in Intelligent Systems and Computing, vol 177. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31552-7_64 DOI: https://doi.org/10.1007/978-3-642-31552-7_64

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Published

15-11-2025

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Section

Research Articles

How to Cite

[1]
Lila Misra and Dr. Rahul Shrivastava, “A Comparative Analysis of CNN, XG Boost, DNN and Res Net for Leukemia Classification Using Hybrid PSO Model”, Int. J. Sci. Res. Comput. Sci. Eng. Inf. Technol, vol. 11, no. 6, pp. 193–200, Nov. 2025, doi: 10.32628/CSEIT2511630.